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长期外源性类固醇治疗疑诊为巨细胞动脉炎所致的艾迪生病被掩盖。

Addison's disease masked by long-term exogenous steroid treatment for presumed polymyalgia rheumatica.

机构信息

Department of Acute Medicine, The James Cook University Hospital, Middlesbrough.

出版信息

Clin Med (Lond). 2012 Feb;12(1):89-90. doi: 10.7861/clinmedicine.12-1-89.

DOI:10.7861/clinmedicine.12-1-89
PMID:22372233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4953431/
Abstract

Addison's disease can present insidiously. A 78-year-old woman presented with non-specific symptoms and hyponatremia, with a previous history of polymyalgia rheumatica treated with glucocorticoids. Subsequent investigations were consistent with primary rather than secondary adrenal failure. Primary autoimmune Addison's disease can present with protean symptoms and diagnosis is often delayed. A high index of suspicion remains the cornerstone of diagnosis.

摘要

艾迪生病可能隐匿起病。一位 78 岁女性以非特异性症状和低钠血症就诊,此前曾患有巨细胞动脉炎,接受过糖皮质激素治疗。后续检查结果与原发性而非继发性肾上腺功能衰竭一致。原发性自身免疫性艾迪生病可能表现出多种症状,且诊断常常被延误。保持高度怀疑是诊断的基石。

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本文引用的文献

1
Delayed diagnosis of adrenal insufficiency is common: a cross-sectional study in 216 patients.肾上腺功能不全的延迟诊断很常见:216 例患者的横断面研究。
Am J Med Sci. 2010 Jun;339(6):525-31. doi: 10.1097/MAJ.0b013e3181db6b7a.
2
Addison's disease.艾迪生病
Autoimmunity. 2004 Jun;37(4):333-6. doi: 10.1080/08916930410001705466.
3
Is the prevalence of Addison's disease underestimated?阿狄森氏病的患病率是否被低估了?
J Clin Endocrinol Metab. 1999 May;84(5):1762. doi: 10.1210/jcem.84.5.5677-7.
4
Primary adrenocortical failure masked by exogenous steroid administration.
Clin Endocrinol (Oxf). 1992 May;36(5):519-20. doi: 10.1111/j.1365-2265.1992.tb02255.x.