Pakosova E, Timarova G, Krivosik M, Lisa I, Martinkova J, Kukumberg P
2nd Department of Neurology, Faculty Hospital of Comenius University, Bratislava, Slovakia.
Bratisl Lek Listy. 2011;112(12):691-4.
Idiopathic intracranial hypertension is a disorder characterized by an increased intracranial pressure, without deformity and obstruction of the ventricular system. There is a predilection of occurrence in obese women of childbearing age. The pathogenesis of idiopathic intracranial hypertension is likely related to abnormalities in the balance between production and drainage of cerebrospinal fluid. Diagnosis is made by excluding the known causes of elevated intracranial pressure.
To evaluate the features, possible causes, treatment, and incidence of idiopathic intracranial hypertension as seen in patients attending our Department of Neurology.
We retrospectively analysed a group of patients diagnosed with idiopathic intracranial hypertension in our Department of Neurology during a twenty-year period (1989 to 2008).
In six patients we confirmed the diagnosis of idiopathic intracranial hypertension during this period. Five of them were females and one was male, the average age of the patients was 32.30 years (22 to 52). The calculated incidence of idiopathic intracranial hypertension in our group was 0.15 per 100,000 persons. Out of these six persons there were four cases diagnosed in the last five years, changing the calculated incidence to 0.4 per 100,000 persons in this period. The average body mass index in our patients was 26.33 kg/m2 (20.1 to 31.38).
We suppose that the increased incidence of idiopathic intracranial hypertension in our patients in the last five years has been associated with an advance in diagnostics. With literary data, half of our patients were obese or overweighted, but all of them underwent also hormonal treatment, some had iron deficiency and one of them was pregnant (Tab. 3, Fig. 1, Ref. 17). Full Text in free PDF www.bmj.sk.
特发性颅内高压是一种以颅内压升高为特征的疾病，脑室系统无畸形和梗阻。好发于育龄肥胖女性。特发性颅内高压的发病机制可能与脑脊液生成与引流平衡异常有关。通过排除已知的颅内压升高原因进行诊断。
评估我院神经内科就诊患者中特发性颅内高压的特征、可能病因、治疗及发病率。
我们回顾性分析了我院神经内科在20年期间（1989年至2008年）诊断为特发性颅内高压的一组患者。
在此期间，我们确诊了6例特发性颅内高压患者。其中5例为女性，1例为男性，患者平均年龄为32.30岁（22至52岁）。我们组中特发性颅内高压的计算发病率为每10万人0.15例。在这6例患者中，有4例是在过去5年中诊断出来的，这使得此期间的计算发病率变为每10万人0.4例。我们患者的平均体重指数为26.33kg/m²（20.1至31.38）。
我们推测，过去5年我们患者中特发性颅内高压发病率的增加与诊断技术的进步有关。根据文献数据，我们一半的患者肥胖或超重，但他们都接受了激素治疗，一些人有缺铁情况，其中1人怀孕（表3，图1，参考文献17）。免费PDF全文www.bmj.sk 。
