Aragonès Gerard, Ercilla Amaia, Barreda María, Rull Anna, Beltrán-Debón Raúl, Rodríguez-Gallego Esther, Alonso-Villaverde Carlos, Camps Jordi, Joven Jorge
Centre de Recerca Biomèdica, Universitat Rovira i Virgili, Hospital Universitari de Sant Joan, IISPV, Reus, Spain.
Clin Lab. 2012;58(1-2):185-8.
We explored whether the Asp42Gly polymorphism (rs12075) in the DARC gene represents a confounding factor in the interpretation of monocyte chemoattractant protein-1 (MCP-1) concentration in circulating blood.
MCP-1 concentration in serum and plasma were measured in 278 healthy Caucasian participants who are representative of our geographic area. The rs12075 genotype distribution was also assessed in this population.
Plasma MCP-1 concentration did not vary among the rs12075 polymorphism derived genotypes [in pg/mL, AA: 171.9 (100.2 - 287.2), AG: 178.9 (105.1 - 326.4) and GG: 173.7 (94.4 - 405.7)]. However, there were significant increases in serum MCP-1 related to the presence of the A allele [in pg/mL, AA: 334.6 (180.4 - 756.4), AG: 299.1 (166.1 - 634.9) and GG: 249.1 (149.3 - 578.1)].
These findings limit the value of circulating MCP-1 as a biomarker and apparently indicate a pathophysiological role for silent chemokine receptors.
我们探讨了DARC基因中的Asp42Gly多态性（rs12075）是否在解释循环血液中单核细胞趋化蛋白-1（MCP-1）浓度时代表一个混杂因素。
在代表我们地理区域的278名健康白种人参与者中测量血清和血浆中的MCP-1浓度。还评估了该人群中rs12075基因型分布。
血浆MCP-1浓度在rs12075多态性衍生的基因型之间没有差异[以pg/mL计，AA：171.9（100.2 - 287.2），AG：178.9（105.1 - 326.4）和GG：173.7（94.4 - 405.7）]。然而，与A等位基因的存在相关的血清MCP-1有显著增加[以pg/mL计，AA：334.6（180.4 - 756.4），AG：299.1（166.1 - 634.9）和GG：249.1（149.3 - 578.1）]。
这些发现限制了循环MCP-1作为生物标志物的价值，并且显然表明沉默趋化因子受体具有病理生理作用。
