Department of Tea Science, Zhejiang University, Hangzhou 310058, PR China.
Mini Rev Med Chem. 2012 Feb;12(2):120-6. doi: 10.2174/138955712798995011.
The biological activities and mechanisms of tea polyphenols and their polymerics have been attractive issues in cancer research. The inhibition of tea polyphenols on cancer cells decreased cell proliferation and increased apoptosis. Tremendous evidences have shown that tea polyphenols suppress tumor promotion by inhibiting enzyme activities and blocking signal transduction pathways. Specifically, the mitogen activated protein kinases (MAPK) pathways have been implicated as an important target molecular for cancer prevention and therapy. The purpose of this review is to discuss the relationship between tea polyphenols and MAPK signaling pathways in cancer.
茶多芬及其聚合物的生物活性和机制一直是癌症研究中的热门问题。茶多芬对癌细胞的抑制作用降低了细胞增殖并增加了细胞凋亡。大量证据表明，茶多芬通过抑制酶活性和阻断信号转导途径来抑制肿瘤促进作用。具体而言，丝裂原激活蛋白激酶（MAPK）途径已被认为是癌症预防和治疗的重要靶分子。本综述的目的是讨论茶多芬与癌症中 MAPK 信号通路的关系。
