Vesalius Research Center, VIB, Campus Gasthuisberg, Leuven, Belgium.
Traffic. 2012 Jun;13(6):771-9. doi: 10.1111/j.1600-0854.2012.01347.x. Epub 2012 Mar 26.
Histone deacetylase 6 (HDAC6) catalyzes multiple reactions. We summarize the current knowledge on HDAC6, its targets and functions. Among others, HDAC6 recognizes damaged proteins and assures that these proteins are destroyed by autophagy. On the other hand, HDAC6 also modifies the tracks used by the clearance mechanism so that axonal transport becomes less efficient. We hypothesize that a disturbance in the equilibrium between the different functions of HDAC6 could play an important role in neurodegeneration.
组蛋白去乙酰化酶 6（HDAC6）催化多种反应。我们总结了 HDAC6 的当前知识，包括其靶标和功能。HDAC6 识别受损蛋白质并确保这些蛋白质被自噬所破坏。另一方面，HDAC6 还修饰了清除机制所使用的轨道，从而降低了轴突运输的效率。我们假设，HDAC6 的不同功能之间平衡的失调可能在神经退行性变中起重要作用。
