Gerdes S, Mrowietz U
Psoriasis-Zentrum an der Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schittenhelmstr. 7, 24105, Kiel, Deutschland.
Hautarzt. 2012 Mar;63(3):202-13. doi: 10.1007/s00105-011-2230-x.
Psoriasis is a genetically determined, chronic inflammatory systemic disease. Besides skin symptoms, patients with moderate to severe forms of psoriasis show an association with other diseases, referred to as comorbidities. Metabolic disorders (e.g. diabetes mellitus, insulin resistance, dyslipidemia mainly in obese patients) and cardiovascular diseases (e.g. arterial hypertension, coronary artery disease, myocardial infarction and stroke) are of importance as they can increase patients' mortality. In addition, psychiatric diseases are more frequent in psoriasis patients and influence the therapeutic approach. The dermatologist in most cases is the primarily consulted physician for patients with psoriasis and therefore plays the role as a gatekeeper managing therapy. He is responsible for the early diagnosis of comorbidities and insuring their appropriate management. The anti-psoriatic treatment has to be adapted to existing comorbidities and their systemic treatments. The following article provides information on psoriatic comorbidities and their consequences for daily practice.
银屑病是一种由基因决定的慢性炎症性全身性疾病。除皮肤症状外，中重度银屑病患者还与其他疾病相关，即合并症。代谢紊乱（如糖尿病、胰岛素抵抗、主要见于肥胖患者的血脂异常）和心血管疾病（如动脉高血压、冠状动脉疾病、心肌梗死和中风）很重要，因为它们会增加患者的死亡率。此外，银屑病患者中精神疾病更为常见，并影响治疗方法。在大多数情况下，皮肤科医生是银屑病患者首先咨询的医生，因此扮演着管理治疗的把关人角色。他负责合并症的早期诊断并确保其得到适当管理。抗银屑病治疗必须根据现有的合并症及其全身治疗进行调整。以下文章提供了有关银屑病合并症及其对日常实践影响的信息。
