磷酸肌醇在神经元突触中的作用。
Role of phosphoinositides at the neuronal synapse.
作者信息
Frere Samuel G, Chang-Ileto Belle, Di Paolo Gilbert
机构信息
Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, P&S 12-420C, 10032, New York, USA.
出版信息
Subcell Biochem. 2012;59:131-75. doi: 10.1007/978-94-007-3015-1_5.
Synaptic transmission is amongst the most sophisticated and tightly controlled biological phenomena in higher eukaryotes. In the past few decades, tremendous progress has been made in our understanding of the molecular mechanisms underlying multiple facets of neurotransmission, both pre- and postsynaptically. Brought under the spotlight by pioneer studies in the areas of secretion and signal transduction, phosphoinositides and their metabolizing enzymes have been increasingly recognized as key protagonists in fundamental aspects of neurotransmission. Not surprisingly, dysregulation of phosphoinositide metabolism has also been implicated in synaptic malfunction associated with a variety of brain disorders. In the present chapter, we summarize current knowledge on the role of phosphoinositides at the neuronal synapse and highlight some of the outstanding questions in this research field.
突触传递是高等真核生物中最复杂且受到严格调控的生物现象之一。在过去几十年里，我们对神经传递多个方面（包括突触前和突触后）的分子机制的理解取得了巨大进展。磷酸肌醇及其代谢酶在分泌和信号转导领域的开创性研究使其成为焦点，它们在神经传递的基本方面越来越被视为关键角色。不出所料，磷酸肌醇代谢失调也与多种脑部疾病相关的突触功能障碍有关。在本章中，我们总结了目前关于磷酸肌醇在神经元突触中作用的知识，并强调了该研究领域一些突出的问题。
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