Advanced Elements Chemistry Research Team, Advanced Science Institute, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan.
Chemistry. 2012 Mar 19;18(12):3482-5. doi: 10.1002/chem.201103784. Epub 2012 Feb 28.
An etheric Negishi coupling: The first cross-coupling reaction between aryl alkyl ethers and dianion-type zincate reagents to afford biaryl compounds through selective cleavage of the etheric C(sp(2))-O bond was developed. Dianion-type zincates showed excellent reactivity toward the aromatic ethers under mild conditions, with good functional group compatibility (see scheme).
醚型 Negishi 偶联反应：开发了芳基烷基醚与二价锌试剂之间的首次交叉偶联反应，通过选择性断裂醚的 C(sp(2))-O 键，生成联苯化合物。在温和条件下，二价锌试剂对芳基醚表现出极好的反应活性，具有良好的官能团相容性（见方案）。
