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N-甲基-3-苯基-降冰片烷-2-胺(卡非他命™)的合成与表征。

The synthesis and characterization N-methyl-3-phenyl-norbornan-2-amine (Camfetamine™).

机构信息

Department of Pharmacology and Therapeutics, School of Medicine, Trinity Centre for Health Sciences, St James's Hospital, Dublin, Ireland.

出版信息

Drug Test Anal. 2013 Apr;5(4):247-53. doi: 10.1002/dta.411. Epub 2012 Feb 28.

Abstract

N-Methyl-3-phenyl-norbornan-2-amine (N-methyl-3-phenylbicyclo[2.2.1]heptan-2-amine, Camfetamine(™) ) is available from a number of online legal highs/research chemicals' vendors. Although it was developed as an analeptic by Merck in the early 1960s, it was never commercialized. However, the Association of Independent Research Chemical Retailers (AIRCR), an umbrella organization for a number of online vendors, has redeveloped it for use as a recreational drug. N-Methyl-3-phenyl-norbornan-2-amine is closely related to fencamfamine which has been widely used as a central nervous system (CNS) stimulant and appetite suppressant. In this paper we describe the synthesis of N-methyl-3-phenyl-norbornan-2-amine, its characterization and interpretations of its electron impact, and electrospray ionization mass spectra.

摘要

N-甲基-3-苯基-2-降冰片胺(N-甲基-3-苯基双环[2.2.1]庚烷-2-胺,卡非他命(™))可从许多在线合法兴奋剂/研究用化学品供应商处获得。尽管它是由默克公司在 20 世纪 60 年代早期开发的一种苏醒剂,但从未商业化。然而,一个名为独立研究化学品零售商协会(AIRCR)的在线供应商伞式组织对其进行了重新开发,将其用作娱乐性药物。N-甲基-3-苯基-2-降冰片胺与芬坎法明密切相关,芬坎法明已被广泛用作中枢神经系统(CNS)兴奋剂和食欲抑制剂。在本文中,我们描述了 N-甲基-3-苯基-2-降冰片胺的合成、其特征及其电子冲击和电喷雾电离质谱的解释。

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