Department of Cell Biology, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Sci Signal. 2012 Feb 28;5(213):pe7. doi: 10.1126/scisignal.2002839.
Actin polymerization is fundamental to many cellular activities, including motility, cytokinesis, and vesicle traffic. Actin dynamics must be tightly regulated so that cells execute a response appropriate to need, which is achieved through coordination of the functions of a molecular toolkit of proteins and phospholipids. Among the latter, phosphoinositides have a particularly important role, and PI(4,5)P₂ (phosphatidylinositol 4,5-bisphosphate) generates distinct phenotypic outcomes such as actin comet formation and membrane ruffling. New evidence reveals that it is not just the production of PI(4,5)P₂ that is important in determining outcome, but that changes in the abundance of other phosphoinositides also play a role.
肌动蛋白聚合是许多细胞活动的基础，包括运动、胞质分裂和囊泡运输。肌动蛋白动力学必须受到严格调控，以使细胞对需要做出适当的反应，这是通过协调蛋白质和磷脂的分子工具包的功能来实现的。在后者中，磷酸肌醇具有特别重要的作用，PI(4,5)P₂（磷脂酰肌醇 4,5-二磷酸）产生不同的表型结果，如肌动蛋白彗星形成和细胞膜皱襞。新的证据表明，决定结果的不仅仅是 PI(4,5)P₂的产生，其他磷酸肌醇的丰度变化也起着重要作用。
