Insall R H, Weiner O D
School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Dev Cell. 2001 Dec;1(6):743-7. doi: 10.1016/s1534-5807(01)00086-7.
The inositol lipids PI(4,5)P(2) and PI(3,4,5)P(3) are important regulators of actin polymerization, but their different temporal and spatial dynamics suggest that they perform separate roles. PI(3,4,5)P(3) seems to act as an instructive second messenger, inducing local actin polymerization. PI(4,5)P(2) appears to be present at too high a concentration and homogeneous a distribution to fulfil a similar role. Instead, we suggest that PI(4,5)P(2) acts permissively, restricting new actin polymerization to the region of the plasma membrane.
肌醇脂质PI(4,5)P(2)和PI(3,4,5)P(3)是肌动蛋白聚合的重要调节因子，但它们不同的时空动态表明它们发挥着不同的作用。PI(3,4,5)P(3)似乎作为一种指导性的第二信使，诱导局部肌动蛋白聚合。PI(4,5)P(2)的浓度似乎过高且分布过于均匀，无法发挥类似的作用。相反，我们认为PI(4,5)P(2)起允许作用，将新的肌动蛋白聚合限制在质膜区域。
