Pfluger T, Wendt T, Toroutoglou N, Pickardt C, Wuttge R
Radiologische Klinik und Poliklinik Innenstadt, Ludwig-Maximilians-Universität München.
Strahlenther Onkol. 1990 Oct;166(10):673-7.
Severe Graves' ophthalmopathy has been treated in 44 cases by orbital irradiation. 36 out of 37 patients showed a good response or a suspend of the progressive disease. In 17 out of 33 primary irradiations a dose of 10 Gy and in 16 cases a dose of 16 Gy was applied. Measured by ophthalmopathy-index significant better results have been achieved by a total dose of 16 Gy. Because of recurrence after primary irradiation of 10 Gy a re-irradiation became necessary in 35% of the cases. Primary irradiation of 16 Gy has required no further treatment during the same time of observation. A single series of 16 Gy irradiation has shown better results than two series of 10 Gy irradiation concerning the proptosis and alleviation of symptoms.
44例重度格雷夫斯眼病患者接受了眼眶照射治疗。37例患者中有36例病情好转或病情进展得到缓解。33例初次照射中,17例给予10 Gy剂量,16例给予16 Gy剂量。以眼病指数衡量,16 Gy的总剂量取得了明显更好的效果。由于10 Gy初次照射后出现复发,35%的病例需要再次照射。在相同观察期内,16 Gy的初次照射无需进一步治疗。就眼球突出和症状缓解而言,单次16 Gy照射系列比两次10 Gy照射系列显示出更好的效果。