Department of Pathology, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.
Neuroepidemiology. 2012;38(2):106-13. doi: 10.1159/000336013. Epub 2012 Feb 24.
Controversy persists as to whether smoking is a risk factor for sporadic amyotrophic lateral sclerosis (SALS), the most common form of sporadic motor neuron disease (SMND). We therefore undertook a large case-control study of smoking and SALS in Australia.
Cases and controls were recruited Australia-wide over a 10-year period. SALS and the other subgroups of SMND were categorised on the basis of neurologists' reports. Controls were partners or friends of SMND patients or community volunteers. Individuals filled in a questionnaire regarding smoking habits. A total of 809 patients with SMND (631 with SALS) and 779 controls were included in the study. SALS males and females were analysed separately.
No differences between SALS patients and control groups were found with regard to (1) the odds ratios of ever-smokers, ex-smokers or current smokers compared to never-smokers, (2) the means of numbers of cigarettes per day, years of smoking, pack years or age smoking began or (3) the proportions of their parents who had ever smoked. The proportion of ever-smokers and mean pack years did not differ between the clinical subgroups of SMND or between different sites of SALS onset. Partner smoking did not increase the risk of SMND.
This Australian case-control study does not support a link between cigarette smoking and any form of SMND.
吸烟是否是散发性肌萎缩侧索硬化症（SALS）的危险因素，这是散发性运动神经元病（SMND）最常见的形式，目前仍存在争议。因此，我们在澳大利亚进行了一项大型病例对照研究，调查吸烟与 SALS 的关系。
在 10 年的时间里，在澳大利亚各地招募病例和对照。根据神经科医生的报告，将 SALS 和 SMND 的其他亚组进行分类。对照者为 SMND 患者的伴侣或朋友或社区志愿者。个人填写了一份关于吸烟习惯的问卷。共有 809 名 SMND 患者（631 名 SALS 患者）和 779 名对照者纳入研究。对 SALS 男性和女性分别进行了分析。
SALS 患者和对照组之间在以下方面没有差异：（1）与从不吸烟者相比，曾经吸烟者、曾经吸烟者或当前吸烟者的优势比，（2）每天吸烟支数、吸烟年限、吸烟包年数或开始吸烟年龄的平均值，或（3）其父母中曾经吸烟者的比例。SMND 的临床亚组之间或 SALS 发病部位不同，曾经吸烟者的比例和平均吸烟包年数均无差异。伴侣吸烟不会增加 SMND 的风险。
这项澳大利亚病例对照研究不支持吸烟与任何形式的 SMND 之间存在关联。
