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蒙特卡罗法评估直接接触含常见生物技术同位素溶液的微量离心管时手指浅层剂量。

Monte Carlo assessment of the finger shallow dose from direct contact with a microcentrifuge tube containing common biotechnology isotopes in solution.

机构信息

University of Massachusetts, Lowell, USA.

出版信息

Health Phys. 2012 Apr;102(4):453-8. doi: 10.1097/HP.0b013e31823faea5.

DOI:10.1097/HP.0b013e31823faea5
PMID:22378207
Abstract

Eppendorf tubes often are used in biomedical research labs and contain radioactive tracers. Although the associated direct contact finger doses are typically small, it is suggested (and in line with the principle of ALARA) to handle these tubes from the cap of the tube. When containing radioactive material, handling a tube near the bottom conical section would unnecessarily increase the skin dose to the fingers. This investigation modeled a 2.0-mL Eppendorf tube containing various individual beta emitting isotopes commonly used in a biomedical research environment (i.e., (14)C, (3)H, (131)I, (32)P, and (35)S) to determine the skin dose when directly handling the tube at the cap end and when handling it at the bottom conical section. The primary goal of this paper is to assess how significantly this dose is altered by handling geometry. The skin dose to a single finger was calculated with Monte Carlo simulations using MCNP5 and determined at a depth of 0.007 cm(2) in water averaged over 10 cm as described in 10CFR20. Results show that the dose rate may vary by as much as a factor of 700 depending on handling geometry.

摘要

Eppendorf 管常用于生物医学研究实验室,其中含有放射性示踪剂。虽然与之相关的直接接触手指剂量通常较小,但建议(并符合 ALARA 原则)从管盖处理这些管。当含有放射性物质时,在靠近底部锥形部分处理管会不必要地增加手指的皮肤剂量。这项研究模拟了一个 2.0 毫升的 Eppendorf 管,其中含有生物医学研究环境中常用的各种单一β发射同位素(即 (14)C、(3)H、(131)I、(32)P 和 (35)S),以确定直接在管盖端处理管和在底部锥形部分处理管时的皮肤剂量。本文的主要目的是评估处理几何形状如何显著改变这种剂量。使用 MCNP5 通过蒙特卡罗模拟计算单个手指的皮肤剂量,并按照 10CFR20 中的描述,在水中 0.007 cm(2) 的深度处计算 10 cm 处的平均剂量。结果表明,处理几何形状的不同,剂量率可能相差高达 700 倍。

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