Pasi K J, Enayat M S, Horrocks P M, Wright A D, Hill F G
Department of Haematology, Children's Hospital, Birmingham, U.K.
Thromb Res. 1990 Aug 1;59(3):581-91. doi: 10.1016/0049-3848(90)90417-b.
Previous reported studies of vVWf antigen (vWf:Ag) in patients with diabetes mellitus have not shown qualitative abnormalities despite frequent documentation of raised vWf:Ag. Twenty two patients with established diabetes mellitus have been studied and qualitative abnormalities of vWf:Ag multimers were found in 10 patients who had poorer glycaemic control (as judged by plasma fructosamine) than the other 12 patients. Seven of the 22 patients were restudied after a 3 month period of improved glycaemic control and the vWf:Ag multimer abnormalities disappeared in 6 of these. Some of the structural abnormalities were accompanied by loss of vWf functional activity. As vWf:Ag is synthesised in the endothelial cell, vWf:Ag abnormalities during periods of poor glycaemic control may reflect endothelial cell damage with vWf:Ag release and possibly subsequent proteolysis.
先前关于糖尿病患者血管性血友病因子抗原（vWf:Ag）的研究报告显示，尽管经常记录到vWf:Ag升高，但并未发现其存在定性异常。本研究对22例确诊的糖尿病患者进行了观察，发现其中10例血糖控制较差（以血浆果糖胺判断）的患者，其vWf:Ag多聚体存在定性异常，而另外12例患者则无此异常。22例患者中有7例在血糖控制改善3个月后再次接受检查，其中6例患者的vWf:Ag多聚体异常消失。部分结构异常伴有vWf功能活性丧失。由于vWf:Ag在内皮细胞中合成，血糖控制不佳时出现的vWf:Ag异常可能反映了内皮细胞损伤，导致vWf:Ag释放，并可能随后发生蛋白水解。
