Department of Surgery, University of Pennsylvania, Glenolden, Pennsylvania 19036-2307, USA.
Neurourol Urodyn. 2012 Mar;31(3):352-8. doi: 10.1002/nau.21228. Epub 2012 Feb 29.
Normal functioning of the urinary bladder and the distal gut is an essential part of daily physiological activity coordinated by the peripheral and central nervous systems. Pathological changes in one of these organs may induce the development of cross-organ sensitization in the pelvis and underlie clinical co-morbidity of genitourinary and GI dysfunctions. Experimental human and animal data suggest that the bladder and distal colon interact under both normal and pathological conditions, however, the directions of these interactions can change dramatically depending on the nature and duration of the applied stimuli. This review article aimed to summarize the clinical data on colon-bladder cross-reflexes in healthy individuals, as well as in patients with co-morbid disorders. It also discusses currently used animal models, experimental approaches, and suggested mechanisms of colon-bladder cross-talk. Additionally, it provides an overview of the potential pharmacological targets to develop treatment options for patients with co-morbid disorders. Presented work resulted from the discussion of colon/bladder interactions during "Think Tank 9" presentations at the International Consultation on Incontinence Research Society meeting held in Bristol, UK, 2011.
正常的膀胱和远端肠道功能是外周和中枢神经系统协调的日常生理活动的重要组成部分。这些器官中的一个器官的病理变化可能会导致骨盆中的跨器官敏化的发展，并构成泌尿生殖和胃肠道功能障碍的临床共病的基础。实验性的人和动物数据表明，在正常和病理条件下，膀胱和远端结肠相互作用，然而，这些相互作用的方向可以根据所施加刺激的性质和持续时间而发生显著变化。这篇综述文章旨在总结关于健康个体以及共病患者的结肠-膀胱交叉反射的临床数据。它还讨论了目前使用的动物模型、实验方法和建议的结肠-膀胱交叉对话的机制。此外，它还概述了为共病患者开发治疗选择的潜在药理学靶点。目前的工作是在 2011 年于英国布里斯托尔举行的国际尿失禁研究学会会议的“Think Tank 9”会议上讨论结肠/膀胱相互作用的结果。
