CD4+ T 细胞与 HIV：一种矛盾的双人舞。
CD4+ T cells and HIV: A paradoxical Pas de Deux.
机构信息
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Sci Transl Med. 2012 Feb 29;4(123):123ps4. doi: 10.1126/scitranslmed.3003862.
When it comes to HIV infection, CD4(+) T cells are usually thought of as the cells that are preferentially infected and killed by the virus. In a new study, Soghoian et al. now show that during the early stages of HIV infection, CD4(+) T cells suppress virus replication and delay disease onset. Thus, the robustness of the CD4(+) T cell response during early HIV infection could be used as a marker to determine the speed of disease progression. The new findings also have implications for the design of preventive and therapeutic AIDS vaccines.
当涉及 HIV 感染时，CD4(+) T 细胞通常被认为是优先被病毒感染和杀死的细胞。在一项新的研究中，Soghoian 等人现在表明，在 HIV 感染的早期阶段，CD4(+) T 细胞抑制病毒复制并延迟疾病发作。因此，在 HIV 感染的早期阶段，CD4(+) T 细胞反应的稳健性可以用作确定疾病进展速度的标志物。新的发现也对预防性和治疗性艾滋病疫苗的设计具有重要意义。
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