Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Sci Transl Med. 2012 Feb 29;4(123):123ps4. doi: 10.1126/scitranslmed.3003862.
When it comes to HIV infection, CD4(+) T cells are usually thought of as the cells that are preferentially infected and killed by the virus. In a new study, Soghoian et al. now show that during the early stages of HIV infection, CD4(+) T cells suppress virus replication and delay disease onset. Thus, the robustness of the CD4(+) T cell response during early HIV infection could be used as a marker to determine the speed of disease progression. The new findings also have implications for the design of preventive and therapeutic AIDS vaccines.
当涉及 HIV 感染时，CD4(+) T 细胞通常被认为是优先被病毒感染和杀死的细胞。在一项新的研究中，Soghoian 等人现在表明，在 HIV 感染的早期阶段，CD4(+) T 细胞抑制病毒复制并延迟疾病发作。因此，在 HIV 感染的早期阶段，CD4(+) T 细胞反应的稳健性可以用作确定疾病进展速度的标志物。新的发现也对预防性和治疗性艾滋病疫苗的设计具有重要意义。
