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保加利亚心脏黏液瘤的发病率及手术相关情况

Incidences and surgical aspects of cardiac myxomas in Bulgaria.

作者信息

Tschirkov A, Michev B, Topalov V, Michailov D, Jurukova Z, Petkov R

机构信息

National Heart Center, Clinic for Cardiovascular Surgery, Sofia, Bulgaria.

出版信息

Thorac Cardiovasc Surg. 1990 Aug;38 Suppl 2:196-200. doi: 10.1055/s-2007-1014066.

Abstract

63 patients with cardiac tumors underwent operative treatment between January 1970 and December 1988. Three additional patients refused the operation, despite the large left atrial myxomas and obstruction of the mitral valve, recognized by echocardiography. 62 patients had benign tumors: the only malignant neoplasm was a fibrosarcoma, originating from the right ventricle. Myxomas were found in 57 patients: 54 were located in the left and 2 in the right atrium. In one case the myxoma originated from the left ventricle. The hospital mortality of the 22 patients who underwent excision of cardiac myxomas between 1970 and 1984 was 18.18% (4 deaths), and 2.44% (1 death) of 41 patients operated on from 1984 to 1988 for cardiac tumors (35 of them with myxomas). During the follow-up time of 6 to 140 months, recurrence of myxomas occurred in only one patient, 4 years after surgery for multifocal myxoma in the left atrium. Surgical excision of the myxoma is the only acceptable therapy able to cure. Without surgical treatment, the medium and long-term prognosis is fatal. Therefore once the cardiac myxoma is identified by two-dimensional echocardiography, the tumor should be removed even in patients without symptoms. The removal of myxomas doesn't require excision of the full thickness of the interatrial septum or ventricular wall. The risk of postoperative arrhythmias after extensive excision increases. Conduction disturbances may be related to the resection of a large area of the atrial septum or wall. No recurrences have been registered after less radical procedures-- removal with excision only of the underlying endocard.

摘要

1970年1月至1988年12月期间,63例心脏肿瘤患者接受了手术治疗。另有3例患者尽管经超声心动图检查发现有巨大左房黏液瘤并伴有二尖瓣梗阻,但仍拒绝手术。62例患者患有良性肿瘤:唯一的恶性肿瘤是起源于右心室的纤维肉瘤。57例患者发现有黏液瘤:54例位于左心房,2例位于右心房。1例黏液瘤起源于左心室。1970年至1984年期间接受心脏黏液瘤切除术的22例患者的医院死亡率为18.18%(4例死亡),1984年至1988年期间接受心脏肿瘤手术(其中35例为黏液瘤)的41例患者的死亡率为2.44%(1例死亡)。在6至140个月的随访期内,仅1例患者在左心房多灶性黏液瘤手术后4年出现黏液瘤复发。手术切除黏液瘤是唯一能够治愈的可接受治疗方法。未经手术治疗,中、长期预后是致命的。因此,一旦二维超声心动图确诊心脏黏液瘤,即使无症状患者也应切除肿瘤。切除黏液瘤无需切除房间隔或室壁的全层。广泛切除术后心律失常的风险增加。传导障碍可能与大面积房间隔或室壁切除有关。在采取不太彻底的手术——仅切除下层心内膜后未出现复发情况。

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