Koury Joseph P, Burke Charles T
Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Semin Intervent Radiol. 2011 Mar;28(1):3-9. doi: 10.1055/s-0031-1272975.
Upper extremity deep venous thrombosis (UEDVT), though less common than lower extremity DVT, is a significant problem with several possible etiologies. The incidence of UEDVT is on the rise, primarily from the increasing use of central venous access devices. However, there are other causes of UEDVT, including primary venous thrombosis (Paget-Schroetter syndrome) and hypercoagulable states associated with underlying malignancy. The morbidity and mortality associated with UEDVT is largely from pulmonary embolism and the postphlebitic syndrome. Nevertheless, many UEDVTs are asymptomatic or patients may present with nonspecific clinical symptoms; therefore, a high index of suspicion is often necessary to make a correct diagnosis. Currently, there is no standard treatment algorithm for UEDVT. Treatment options may range from systemic anticoagulation to surgical correction depending on the etiology of the thrombus, as well as the patient's associated comorbidities, life expectancy and expected quality of life following treatment.
上肢深静脉血栓形成(UEDVT)虽然不如下肢深静脉血栓形成(DVT)常见,但却是一个有多种可能病因的重要问题。UEDVT的发病率正在上升,主要原因是中心静脉通路装置的使用增加。然而,UEDVT还有其他原因,包括原发性静脉血栓形成(Paget-Schroetter综合征)以及与潜在恶性肿瘤相关的高凝状态。与UEDVT相关的发病率和死亡率主要源于肺栓塞和血栓形成后综合征。尽管如此,许多UEDVT患者无症状,或者可能表现出非特异性临床症状;因此,通常需要高度怀疑才能做出正确诊断。目前,对于UEDVT尚无标准的治疗方案。治疗选择可能从全身抗凝到手术矫正,这取决于血栓的病因以及患者的相关合并症、预期寿命和治疗后的预期生活质量。