Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York, Stony Brook, NY 11794-5222, USA.
Mol Microbiol. 2012 May;84(3):401-4. doi: 10.1111/j.1365-2958.2012.08030.x. Epub 2012 Apr 4.
Studies on the regulatory RNA MicF in Enterobacteriaceae reveal a pivotal role in gene regulation. Multiple target gene mRNAs were identified and, importantly, MicF RNA regulates the expression of the global regulatory gene lrp (Holmqvist et al., 2012; Corcoran et al., 2012). Thus MicF RNA is a central factor in a regulatory network that regulates bacterial cell physiology.
在肠杆菌科中对调节 RNA MicF 的研究揭示了其在基因调控中的关键作用。已鉴定出多个靶标基因 mRNA,重要的是,MicF RNA 调节全局调节基因 lrp 的表达(Holmqvist 等人,2012 年;Corcoran 等人,2012 年)。因此,MicF RNA 是调节细菌细胞生理学的调控网络中的核心因素。