Loréa N, Van Wijnendaele R
Centre hospitalier Jean Titeca, Bruxelles, Belgique.
Encephale. 2012 Feb;38(1):37-41. doi: 10.1016/j.encep.2011.01.002. Epub 2011 Apr 3.
The diagnosis of patients who have a preoccupation about physical ugliness is not easy. Many diagnoses can be made. Body dysmorphic disorder (BDD) is defined as a preoccupation with an imaginary defect in physical appearance. What seems difficult in this diagnosis is to make the difference between the psychotic and the non-psychotic form of the disorder. If the patient becomes delusional, we have to make the diagnosis of delusional disorder, somatic subtype. Sometimes it is not easy to make the difference between the delusional and non-delusional form of the illness. A good example is the so-called "olfactory reference syndrome" (ORS), which involves the persistent preoccupation with one's body odour. To make it more difficult, the preoccupation with one's appearance can be seen in many other disorders, such as schizophrenia, or major depressive disorders. We present three cases of dysmorphophobic patients, to discuss their diagnosis and show how we have to be careful about this delusional versus non-delusional difference.
The first case is a young man, aged 20 year, who exhibits the typical picture of an ORS. He has probable olfactory hallucinations. He had good response to a treatment combining escitalopram 15mg and risperidone 1mg. The second case had a first appearance of BDD, but he had auditive hallucinations and the evolution showed a pattern more typical of schizophrenia, paranoid subtype. He responded initially to citalopram 20mg and ripseridone 2mg. Sleepy with risperidone, it was shifted to amisulpiride 200mg. After five years, it was possible to stop the amisulpiride, but we had to maintain it to avoid a relapse. The third case is typical of schizophrenia, with a pseudo neurotic aspect, and its course was terrible, with poor response to all neuroleptic therapy, including clozapine.
These three cases are typical of a feature rarely reported in the literature: the delusional aspect of a dysmorphophobic concern. The literature mainly focuses on the more anxious pattern, and so emphasises the treatment with serotoninergic antidepressants. Our cases demonstrate a gradation in the delusional and psychotic aspect. The first case is dubitatively psychotic, the second is an "ambulatory" schizophrenia with a good response to treatment, the third a very destructive disease. In our cases, some features showed in the typical BDD are also present. We question the obsessive compulsive aspect of the disorder, which was present in our three cases. This supports the fact that the dysmorphophobic feature could be considered more like a symptom than a disorder itself. It reminds us to be always looking for the delusional features of a disorder so as to give the appropriate treatment.
诊断那些过度关注身体丑陋的患者并非易事。可能会做出多种诊断。躯体变形障碍(BDD)被定义为对想象中的外貌缺陷过度关注。这种诊断的难点在于区分该障碍的精神病性和非精神病性形式。如果患者出现妄想,我们必须做出妄想性障碍、躯体亚型的诊断。有时区分疾病的妄想性和非妄想性形式并不容易。一个很好的例子就是所谓的“嗅觉参照综合征”(ORS),它涉及对自身体味的持续过度关注。更具挑战性的是,对自身外貌的过度关注在许多其他疾病中也可见到,如精神分裂症或重度抑郁症。我们呈现三例躯体变形恐惧症患者的病例,以讨论他们的诊断,并展示我们在区分这种妄想性与非妄想性差异时必须如何谨慎。
第一例是一名20岁的年轻男性,表现出ORS的典型症状。他可能存在幻嗅。他对艾司西酞普兰15毫克和利培酮1毫克联合治疗反应良好。第二例最初表现为BDD,但他有幻听,病情发展显示出更典型的精神分裂症偏执型模式。他最初对西酞普兰20毫克和利培酮2毫克有反应。因服用利培酮后嗜睡,改为氨磺必利200毫克。五年后,可以停用氨磺必利,但我们必须维持用药以避免复发。第三例是典型的精神分裂症,具有假性神经症样表现,其病程严重,对包括氯氮平在内的所有抗精神病治疗反应不佳。
这三个病例代表了文献中很少报道的一个特征:躯体变形恐惧症的妄想方面。文献主要关注更为焦虑的模式,因此强调使用5-羟色胺能抗抑郁药进行治疗。我们的病例展示了妄想和精神病性方面的一个渐变过程。第一例疑似患有精神病,第二例是对治疗反应良好的“非住院型”精神分裂症,第三例是极具破坏性的疾病。在我们的病例中,典型BDD的一些特征也存在。我们对该障碍的强迫观念方面提出疑问,这在我们的三个病例中都存在。这支持了这样一个事实,即躯体变形恐惧症特征可能更应被视为一种症状而非一种疾病本身。它提醒我们要始终留意一种疾病的妄想特征,以便给予恰当的治疗。