Lightdale C J, Winawer S J, Kurtz R C, Knapper W H
Dig Dis Sci. 1979 Aug;24(8):588-93. doi: 10.1007/BF01333702.
To study the efficacy of standard blood tests of liver function (LFTs) and technetium-99m liver scan followed by laparoscopy in the diagnosis of solid malignant tumors of the liver, 100 consecutive patients were evaluated who had these tests because of clinical suspicion of liver neoplasm. Malignant liver tumors were present in 65 of the 100 patients. Laparoscopy diagnosed 60 of the 65, and the neoplasms were documented pathologically by directed biopsy (92% sensitivity, 100% specificity). In 8 patients, hepatoma was diagnosed and staged for possible resection. A negative "blind" biopsy had been performed in 23 of the 60 patients with liver neoplasms diagnosed at laparoscopy. LFTs and liver scans together were good screening tests (95% sensitivity) but had low specificity (46%). Liver scans also provided information as to probable tumor location in the liver, guiding the insertion site for the laparoscope, and directing deep-needle biopsies if no surface lesions were seen.
为研究标准肝功能血液检查（LFTs）、锝-99m肝脏扫描以及随后的腹腔镜检查在诊断肝脏实性恶性肿瘤中的疗效，对100例因临床怀疑肝脏肿瘤而接受这些检查的连续患者进行了评估。100例患者中有65例存在恶性肝脏肿瘤。腹腔镜检查诊断出65例中的60例，通过定向活检对肿瘤进行了病理记录（敏感性92%，特异性100%）。在8例患者中，诊断出肝癌并对其进行分期以确定是否可能切除。在腹腔镜检查诊断为肝脏肿瘤的60例患者中，有23例进行了阴性“盲目”活检。LFTs和肝脏扫描联合起来是很好的筛查检查（敏感性95%），但特异性较低（46%）。肝脏扫描还提供了有关肝脏中可能肿瘤位置的信息，指导腹腔镜的插入部位，并在未发现表面病变时指导深部针吸活检。
