5-羟色胺 2C 受体在小鼠埋珠行为中的作用。
Role of 5-hydroxytryptamine2C receptors in marble-burying behavior in mice.
机构信息
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
出版信息
Biol Pharm Bull. 2012;35(3):376-9. doi: 10.1248/bpb.35.376.
We examined the role of 5-hydroxytryptamine(2C) (5-HT(2C)) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT(2C) agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT(2C) antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT(2C) receptors play a role in marble-burying behavior in mice.
我们研究了 5-羟色胺（2C）（5-HT（2C））受体在小鼠埋丸行为中的作用。当单独给药时，选择性 5-HT（2C）激动剂 WAY161503（3mg/kg）抑制埋丸行为。此外，选择性 5-HT（2C）拮抗剂 SB242084（3mg/kg）逆转了 2,5-二甲氧基-4-碘苯丙胺（DOI）（1mg/kg）或 WAY161503（3mg/kg）对埋丸行为的抑制。同样，SB242084（1mg/kg）逆转了氟伏沙明（30mg/kg）或帕罗西汀（3mg/kg）对埋丸行为的抑制。这些结果表明 5-HT（2C）受体在小鼠的埋丸行为中起作用。
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