Shinomiya K, Fujii Y, Sugimoto Y, Azuma N, Tokunaga S, Kitazumi K, Kamei C
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Methods Find Exp Clin Pharmacol. 2005 Dec;27(10):685-7. doi: 10.1358/mf.2005.27.10.948883.
The present study was undertaken to investigate the effect of paroxetine, a selective serotonin reuptake inhibitor (SSRI), on marble-burying behavior in mice in comparison with those of fluvoxamine and clomipramine. Marble-burying test is extensively used as an animal model for obsessive/compulsive disorder. A significant inhibition in marble-burying behavior was observed with paroxetine, at a dose of 10 mg/kg. The earlier SSRI, fluvoxamine, also significantly inhibited marble-burying behavior at a dose of 30 mg/kg. Although clomipramine, a tricyclic antidepressant, caused an inhibition in marble-burying behavior, a high dose of 100 mg/kg was needed to show a significant effect. On the other hand, all the drugs used in the present study showed no significant changes in spontaneous locomotor activity at doses inhibiting marble-burying behavior. In conclusion, it was confirmed that paroxetine has a potent inhibitory effect on marble-burying behavior in mice, and could have a similar antiobsessive/anticompulsive activity in human beings.
本研究旨在探讨选择性5-羟色胺再摄取抑制剂（SSRI）帕罗西汀对小鼠埋大理石行为的影响，并与氟伏沙明和氯米帕明进行比较。埋大理石试验被广泛用作强迫症的动物模型。观察到帕罗西汀以10mg/kg的剂量对埋大理石行为有显著抑制作用。较早的SSRI氟伏沙明以30mg/kg的剂量也显著抑制了埋大理石行为。虽然三环类抗抑郁药氯米帕明对埋大理石行为有抑制作用，但需要100mg/kg的高剂量才能显示出显著效果。另一方面，本研究中使用的所有药物在抑制埋大理石行为的剂量下，自发运动活性均无显著变化。总之，证实了帕罗西汀对小鼠埋大理石行为有强效抑制作用，并且在人类中可能具有类似的抗强迫/抗强迫活性。
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