选择性单枚桑葚胚与选择性单枚囊胚移植在体外受精-胚胎移植中的临床结局。
Clinical outcomes of elective single morula embryo transfer versus elective single blastocyst embryo transfer in IVF-ET.
机构信息
Maria Fertility Clinic, Samsung Fire Bldg. 2-1 Beomeo-Dong 3, Suseong-Gu, Daegu, 706-743, Republic of Korea.
出版信息
J Assist Reprod Genet. 2012 May;29(5):423-8. doi: 10.1007/s10815-012-9736-8. Epub 2012 Mar 1.
PURPOSE
To compare the clinical outcomes of elective single morula embryo transfer (eSMET) versus elective single blastocyst embryo transfer (eSBET) in selected patients.
METHODS
This study was a retrospective study which analyzed for 271 cycles in women under 37 years of age who are undergoing their first or second trial of in vitro fertilization-embryo transfer (IVF-ET) from January 2008 to December 2009. The eSMET was performed on day 4 (n = 130) and the eSBET was conducted on day 5 (n = 141).
RESULTS
The clinical pregnancy rate (51.5% vs. 51.8%, p = 0.97), implantation rate (52.3% vs. 52.5%, p = 0.98), and live birth rate (39.2% vs. 44.7%, p = 0.36) were similar in the eSMET and eSBET groups, respectively. The miscarriage rate of the eSMET group (23.9%) was slightly higher than that of the eSBET group (13.7%) (p = 0.12), without reaching statistical significance. There was only one case of monozygotic twin pregnancy in each group.
CONCLUSIONS
The clinical outcomes of day 4 eSMET were comparable to those of day 5 eSBET. Therefore, day 4 eSMET is a viable option or an alternative to day 5 eSBET, with no difference in success rates.
目的
比较选择性单枚桑葚胚（eSMET）移植与选择性单枚囊胚（eSBET）移植在特定患者中的临床结局。
方法
这是一项回顾性研究，分析了 2008 年 1 月至 2009 年 12 月期间年龄在 37 岁以下的首次或第二次体外受精-胚胎移植（IVF-ET）的女性的 271 个周期。第 4 天进行 eSMET（n=130），第 5 天进行 eSBET（n=141）。
结果
eSMET 组和 eSBET 组的临床妊娠率（51.5% vs. 51.8%，p=0.97）、种植率（52.3% vs. 52.5%，p=0.98）和活产率（39.2% vs. 44.7%，p=0.36）相似。eSMET 组的流产率（23.9%）略高于 eSBET 组（13.7%）（p=0.12），但无统计学意义。两组各有一例单卵双胎妊娠。
结论
第 4 天的 eSMET 临床结局与第 5 天的 eSBET 相似。因此，第 4 天的 eSMET 是第 5 天的 eSBET 的可行选择或替代方案，成功率无差异。
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