Llanos A J, Ramachandran J, Creasy R K, Rudolph A M, Serón-Ferré M
Endocrinology. 1979 Sep;105(3):613-7. doi: 10.1210/endo-105-3-613.
To determine the role of other ACTH-like peptides in the regulation of glucocorticoid secretion in fetal sheep, we examined the responses of the adrenal gland of fetal and newborn sheep to comparable single doses of alpha MSH (75 micrograms) or ACTH (50 micrograms) during the last third of gestation and the first month of postnatal life. alpha MSH first increased the plasma glucocorticoid concentration at 121--130 days of gestation [from 16 +/- 1.5 to 36.9 +/- 9 (SE) ng/ml]; the response to alpha MSH persisted on days 131--140 of gestation and during the first month after birth. ACTH first increased the plasma glucocorticoid concentration at 131--140 days of gestation and increased it further in the first month after birth (from 18.9 +/- 3.6 to 97.0 +/- 10 ng/ml). The observations that the adrenal glands of fetuses and newborn lambs responded to alpha MSH at a dose comparable to that of ACTH and that the response to alpha MSH in the fetus preceded the response to ACTH may indicate that adrenal receptors mature during fetal development. These data also suggest that the regulation of the adrenal during fetal life may involve more than one tropic hormone.
为了确定其他促肾上腺皮质激素样肽在调节胎羊糖皮质激素分泌中的作用，我们在妊娠后期和出生后第一个月，检测了胎羊和新生羊肾上腺对同等单剂量α-促黑素（α-MSH，75微克）或促肾上腺皮质激素（ACTH，50微克）的反应。α-MSH在妊娠121 - 130天时首次升高血浆糖皮质激素浓度[从16±1.5升至36.9±9（标准误）纳克/毫升]；在妊娠131 - 140天以及出生后的第一个月，对α-MSH的反应持续存在。ACTH在妊娠131 - 140天时首次升高血浆糖皮质激素浓度，并在出生后的第一个月进一步升高（从18.9±3.6升至97.0±10纳克/毫升）。胎儿和新生羔羊的肾上腺对与ACTH剂量相当的α-MSH有反应，且胎儿对α-MSH的反应先于对ACTH的反应，这些观察结果可能表明肾上腺受体在胎儿发育过程中成熟。这些数据还表明，胎儿期肾上腺的调节可能涉及不止一种促激素。
