Freitag Christine M, Asherson Philip, Hebebrand Johannes
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe-Universität Frankfurt am Main, Deutschordenstraße 50, 60528, Frankfurt am Main, Germany,
Curr Top Behav Neurosci. 2012;12:395-428. doi: 10.1007/7854_2011_178.
After a general introduction into genetic risk factors for child psychiatric disorders, four specific child psychiatric disorders with a strong genetic component, namely, Autism Spectrum Disorders, Attention Deficit / Hyperactivity Disorder, Nocturnal Enuresis, and obesity, are discussed in detail. Recent evidence of linkage, candidate gene, and genome-wide association studies are presented. This chapter ends with a prospectus on further research needs.
在对儿童精神障碍的遗传风险因素进行总体介绍之后,详细讨论了四种具有很强遗传成分的特定儿童精神障碍,即自闭症谱系障碍、注意力缺陷/多动障碍、夜间遗尿症和肥胖症。介绍了连锁研究、候选基因研究和全基因组关联研究的最新证据。本章最后列出了进一步研究需求的计划书。