Lombroso P J, Pauls D L, Leckman J F
Child Study Center, Yale University, New Haven, CT 06510-0009.
J Am Acad Child Adolesc Psychiatry. 1994 Sep;33(7):921-38. doi: 10.1097/00004583-199409000-00001.
This review summarizes research findings on the genetics of several childhood psychiatric disorders.
One hundred fifty papers were reviewed from the past several decades and were selected because they have suggested that genetic factors may play a role in the etiology of certain childhood disorders. This review is not meant to be exhaustive but rather has emphasized those disorders for which a genetic etiology has been proposed by different research groups.
The more classical approaches to genetic research are reviewed and critiqued. The status of research for a number of childhood disorders is summarized. The molecular basis for several developmental disorders is presented and the prospects for arriving at a similar molecular understanding for other childhood psychiatric illnesses are discussed.
Genetic factors play a determining role for certain developmental disorders. However, the molecular basis for other psychiatric disorders has yet to be elucidated and there are complicating factors that bear on genetic research of complex behavioral disorders.
本综述总结了关于几种儿童精神疾病遗传学的研究发现。
回顾了过去几十年的150篇论文，这些论文被选中是因为它们表明遗传因素可能在某些儿童疾病的病因中起作用。本综述并非详尽无遗，而是着重于不同研究小组提出有遗传病因的那些疾病。
对更经典的遗传研究方法进行了回顾和批判。总结了一些儿童疾病的研究现状。介绍了几种发育障碍的分子基础，并讨论了对其他儿童精神疾病达成类似分子理解的前景。
遗传因素在某些发育障碍中起决定性作用。然而，其他精神疾病的分子基础尚未阐明，并且存在影响复杂行为障碍遗传研究的复杂因素。
