Neurology Department, Hospital de Cabueñes, Gijón, Spain.
Adv Ther. 2012 Mar;29(3):267-75. doi: 10.1007/s12325-012-0005-0. Epub 2012 Feb 28.
Endermology is a mechanical massage therapy that enables fat mobilization and body contouring. The authors' aim was to assess the effect of endermology on indurations and panniculitis/lipoatrophy associated with subcutaneous administration of glatiramer acetate in patients with multiple sclerosis (MS).
This was a multicenter pilot experience carried out in patients with MS treated with glatiramer acetate who showed indurations and/ or panniculitis/lipoatrophy at the injection site. Patients underwent endermology and glatiramer acetate treatment according to clinical practice. The primary endpoint was the change in indurations and/or panniculitis/lipoatrophy after 12 endermology sessions.
Between April and July 2011, a total of 13 evaluable patients were included (mean age, 40.7±3.1 years; female, 100%; white, 100%; mean MS duration, 10.1±2.3 years; previous MS treatment, 46.2%; mean glatiramer acetate treatment duration, 27.3±9.5 months). Eleven patients (84.6%) showed local indurations (mean diameter, 3.4±0.5 cm; mean number, 9.0±1.0) and six patients (46.2%) areas of panniculitis/ lipoatrophy (mean number, 5.0±1.1). After 12 endermology sessions, patients with indurations reported having experienced a reduction in size (10 patients [90.9%]; mean diameter, 0.1±0.05 cm; P<0.001) and number of indurations (nine patients [81.8%]; mean number, 2.3±1.1; P<0.005). These indurations completely disappeared from arms, thighs, buttocks, and abdomen in six (75.0%), six (75.0%), two (50.0%), and three (42.9%) patients, respectively. Three of these patients (27.3%) recovered from all indurations. Although panniculitis/lipoatrophy did not completely disappear, all patients reported improvements. Most patients with indurations (63.6%) felt very satisfied and considered endermology very useful for reducing indurations. All patients with panniculitis/lipoatrophy were satisfied and considered to be endermology useful in improving it. In addition, endermology enabled glatiramer acetate tolerance to be improved in most patients (60.0%).
Endermology may contribute to improving indurations and panniculitis/ lipoatrophy at the site of subcutaneous injection of glatiramer acetate in patients with MS, enabling areas of injection to recover, and treatment tolerance to increase.
按摩疗法是一种机械按摩疗法，可促进脂肪动员和身体塑形。作者的目的是评估按摩疗法对多发性硬化症（MS）患者皮下给予醋酸格拉替雷后硬结和脂膜炎/脂肪萎缩的影响。
这是一项多中心的初步经验，纳入了接受醋酸格拉替雷治疗的多发性硬化症患者，这些患者在注射部位出现硬结和/或脂膜炎/脂肪萎缩。患者根据临床实践接受按摩疗法和醋酸格拉替雷治疗。主要终点是 12 次按摩疗法后硬结和/或脂膜炎/脂肪萎缩的变化。
2011 年 4 月至 7 月期间，共纳入 13 名可评估患者（平均年龄 40.7±3.1 岁；女性 100%；白人 100%；平均多发性硬化症病程 10.1±2.3 年；既往多发性硬化症治疗 46.2%；醋酸格拉替雷治疗平均持续时间 27.3±9.5 个月）。11 名患者（84.6%）出现局部硬结（平均直径 3.4±0.5cm；平均数量 9.0±1.0），6 名患者（46.2%）出现脂膜炎/脂肪萎缩区域（平均数量 5.0±1.1）。经过 12 次按摩治疗后，有硬结的患者报告硬结大小减小（10 名患者[90.9%]；平均直径 0.1±0.05cm；P<0.001）和硬结数量减少（9 名患者[81.8%]；平均数量 2.3±1.1；P<0.005）。在 6 名（75.0%）、6 名（75.0%）、2 名（50.0%）和 3 名（42.9%）患者中，手臂、大腿、臀部和腹部的硬结完全消失。这 3 名患者（27.3%）硬结完全消失。虽然脂膜炎/脂肪萎缩没有完全消失，但所有患者均报告有改善。大多数有硬结的患者（63.6%）感到非常满意，并认为按摩疗法非常有助于减少硬结。所有有脂膜炎/脂肪萎缩的患者都感到满意，并认为按摩疗法有助于改善脂膜炎/脂肪萎缩。此外，按摩疗法使大多数患者（60.0%）对醋酸格拉替雷的耐受性得到改善。
按摩疗法可能有助于改善多发性硬化症患者皮下注射醋酸格拉替雷后硬结和脂膜炎/脂肪萎缩，使注射部位恢复，并提高治疗耐受性。
