School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Eur J Pediatr. 2012 Dec;171(12):1737-46. doi: 10.1007/s00431-012-1701-0. Epub 2012 Mar 1.
The objective of this study is to assess the association between birth weight and overweight/obesity in adults. The following MeSH terms were used: "birth weight," "obesity," "overweight." Fifteen studies involving a total of 211,457 persons were identified. Low birth weight (<2,500 g), as compared with normal birth weight (2,500-4,000 g), was not associated with increased risk of overweight/obesity (OR = 1.17, 95% CI 0.94, 1.46). High birth weight (≥ 4,000 g), as compared with normal birth weight, was associated with increased risk of overweight/obesity (OR = 1.46, 95% CI 1.27, 1.68). Low birth weight compared with normal birth weight, the total mean difference of BMI decreased 0.14 kg/m(2). High birth weight compared with normal birth weight, the total mean difference of BMI increased 0.76 kg/m(2). Low birth weight, as compared with a birth weight of ≥ 2,500 g, was not significantly associated with decreased risk of obesity (OR = 1.12, 95% CI 0.90-1.40). High birth weight, as compared with a birth weight of <4,000 g, was associated with increased risk of obesity (OR = 1.43, 95% CI 1.25-1.64). Low birth weight compared with birth weight ≥ 2,500 g, the total mean difference of BMI was decreased 0.42 kg/m(2); high birth weight compared with birth weight <4,000 g, the total mean difference of BMI was increased 0.79 kg/m(2).
Neither positively linear nor J- or U-shaped relations exist between birth weight and overweight/obesity in adults. It is high birth weight, not low birth weight, that is associated with increased risk of overweight/obesity in adults.
本研究旨在评估出生体重与成年人超重/肥胖的相关性。使用了以下 MeSH 术语：“出生体重”、“肥胖”、“超重”。共确定了 15 项涉及 211457 人的研究。与正常出生体重（2500-4000g）相比，低出生体重（<2500g）与超重/肥胖的风险增加无关（OR=1.17，95%CI 0.94，1.46）。与正常出生体重相比，高出生体重（≥4000g）与超重/肥胖的风险增加相关（OR=1.46，95%CI 1.27，1.68）。与正常出生体重相比，低出生体重的 BMI 总平均差异减少了 0.14kg/m2。与正常出生体重相比，高出生体重的 BMI 总平均差异增加了 0.76kg/m2。与出生体重≥2500g 相比，低出生体重与肥胖风险降低无关（OR=1.12，95%CI 0.90-1.40）。与出生体重<4000g 相比，高出生体重与肥胖风险增加相关（OR=1.43，95%CI 1.25-1.64）。与出生体重≥2500g 相比，低出生体重的 BMI 总平均差异减少了 0.42kg/m2；与出生体重<4000g 相比，高出生体重的 BMI 总平均差异增加了 0.79kg/m2。
出生体重与成年人超重/肥胖之间既不存在正线性关系，也不存在 J 形或 U 形关系。与超重/肥胖风险增加相关的是高出生体重，而不是低出生体重。
