[Comparative analysis of the variants of experimental intra-aural pharmacophysical intervention].

The permeability of the blood-brain barrier of rabbits was measured in response to different methods of endaural pharmacophysical intervention and intravenous injection of radioactive DL (2,3-3H2) leucine. The concentration of labelled leucine was measured in the inner ear fluids. The experiments were performed using 28 rabbits. The maximum amount of the drug entered the labyrinth as a result of endaural superphonoelectrophoresis. In this case the positive effect was reached after a smaller number of therapeutic sessions. This method is recommended for clinical treatment of cochleovestibular lesions.