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[实验性耳内药物物理干预变体的比较分析]

[Comparative analysis of the variants of experimental intra-aural pharmacophysical intervention].

作者信息

Pal'chun V T, Brodskiĭ V Ia, Kriukov A I, Ramazashvili Z I

出版信息

Vestn Otorinolaringol. 1990 Jul-Aug(4):17-20.

PMID:2238341
Abstract

The permeability of the blood-brain barrier of rabbits was measured in response to different methods of endaural pharmacophysical intervention and intravenous injection of radioactive DL (2,3-3H2) leucine. The concentration of labelled leucine was measured in the inner ear fluids. The experiments were performed using 28 rabbits. The maximum amount of the drug entered the labyrinth as a result of endaural superphonoelectrophoresis. In this case the positive effect was reached after a smaller number of therapeutic sessions. This method is recommended for clinical treatment of cochleovestibular lesions.

摘要

通过不同的耳内药物物理干预方法以及静脉注射放射性DL(2,3 - 3H2)亮氨酸,测量了兔子血脑屏障的通透性。在内耳液中测量标记亮氨酸的浓度。实验使用了28只兔子。耳内超声电泳使药物进入内耳的量最大。在这种情况下,较少的治疗疗程后就能达到积极效果。该方法推荐用于耳蜗前庭病变的临床治疗。

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