患有严重颈动脉狭窄和神经功能障碍病史的患者，其血浆内皮脂肪酶水平升高。
Endothelial Lipase Plasma Levels are Increased in Patients With Significant Carotid Artery Stenosis and History of Neurological Impairment.
作者信息
Riederer Monika, Trbušić Matias, Degoricija Vesna, Frank Saša
机构信息
Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria.
出版信息
J Clin Med Res. 2012 Feb;4(1):49-51. doi: 10.4021/jocmr734w. Epub 2012 Jan 17.
BACKGROUND
Endothelial lipase (EL) is a phospholipase expressed predominantly by vascular endothelial cells. The goal of the present study was to examine whether EL plasma levels in patients with carotid artery stenosis differ between those with previous history of neurological impairment and those without neurological symptoms.
METHODS
EL plasma levels were measured by a competitive ELISA assay.
RESULTS
EL plasma levels were significantly higher in the symptomatic, compared with the asymptomatic group (mean 489.61 ± 145 ng/ml (n = 31) vs. 388.39 ± 133 ng/ml (n = 24), t-test, P = 0.011).
CONCLUSION
We concluded that increased EL plasma levels reflect the patients' overall susceptibility for cerebrovascular events.
KEYWORDS
Atherosclerosis; Carotid artery stenosis; Endothelial lipase; Neurological impairment; Carotid endarterectomy.
背景
内皮脂肪酶（EL）是一种主要由血管内皮细胞表达的磷脂酶。本研究的目的是检查有颈动脉狭窄的患者中，既往有神经功能损害病史的患者与无神经症状的患者之间的EL血浆水平是否存在差异。
方法
采用竞争性ELISA法测定EL血浆水平。
结果
有症状组的EL血浆水平显著高于无症状组（平均489.61±145 ng/ml（n = 31）对388.39±133 ng/ml（n = 24），t检验，P = 0.011）。
结论
我们得出结论，EL血浆水平升高反映了患者对脑血管事件的总体易感性。
关键词
动脉粥样硬化；颈动脉狭窄；内皮脂肪酶；神经功能损害；颈动脉内膜切除术。
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