Maiti Debabrata, Fors Brett P, Henderson Jaclyn L, Nakamura Yoshinori, Buchwald Stephen L
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge Massachusetts 02139.
Chem Sci. 2011 Jan 1;2(1):57-68. doi: 10.1039/C0SC00330A.
We report our studies on the use of two catalyst systems, based on the ligands BrettPhos (1) and RuPhos (2), which provide the widest scope for Pd-catalyzed C-N cross-coupling reactions to date. Often low catalyst loadings and short reaction times can be used with functionalized aryl and heteroaryl coupling partners. The reactions are highly robust and can be set up and performed without the use of a glovebox. These catalysts should find wide application in the synthesis of complex molecules including pharmaceuticals, natural products and functional materials.
我们报告了基于配体BrettPhos(1)和RuPhos(2)的两种催化剂体系的研究,这两种催化剂体系为钯催化的C-N交叉偶联反应提供了迄今为止最广泛的适用范围。对于官能化的芳基和杂芳基偶联伙伴,通常可以使用低催化剂负载量和短反应时间。这些反应具有很高的稳健性,无需使用手套箱即可设置和进行。这些催化剂应在包括药物、天然产物和功能材料在内的复杂分子合成中得到广泛应用。