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[妊娠糖尿病女性的母体体重指数、孕期体重增加及其与围产期结局的关联]

[Maternal body mass index and gestational weight gain and their association with perinatal outcome in women with gestational diabetes].

作者信息

Gutaj Paweł, Wender-Ozegowska Ewa, Mantaj Urszula, Zawiejska Agnieszka, Brazert Jacek

机构信息

Klinika Połoznictwa i Chorób Kobiecych, Katedra Ginekologii, Poloinictwa i Onkologii Ginekologicznej, Uniwersytet Medyczny im. K. Marcinkowskiego, Poznań, Polska.

出版信息

Ginekol Pol. 2011 Nov;82(11):827-33.

Abstract

OBJECTIVES

Maternal overweight and obesity constitute the most important factors causing perinatal complications. The purpose of the study was to analyze obstetrical results in overweight/obese pregnant women with gestational diabetes in relation to Institute of Health recommendations concerning gestational weight gain and assessment of the role of prepregnancy BMI in prediction of macrosomia, pregnancy induced hypertension and cesarean deliveries.

MATERIAL AND METHODS

Retrospective analysis of 209 overweight and obese pregnant women with gestational diabetes divided into 4 subgroups according to The National Institute of Health (USA) recommendations. The following data were included in the analysis: gestational week in which GDM was diagnosed; HbA1c level in the first and third trimester just before delivery; incidence of pregnancy induced hypertension; incidence of cesarean deliveries; incidence of macrosomia. The following data of II, III, IV subgroups were compared to these found in I subgroup which was classified as the control group. Selected obstetric parameters were also compared between subgroups II, III, IV RESULTS: The selected parameters of subgroups II, III, IV were not significantly different from these of subgroup I. Pregnancy induced hypertension was diagnosed more frequently among subgroup II in comparison to subgroup III. Using ROC curves analysis, the role of pre-pregnancy BMI was found in the prognosis of: birth weight greater than 4300 g, pregnancy induced hypertension, cesarean delivery

CONCLUSIONS

  1. The application of the National Institute of Health recommendations on gestational weight gain is limited in case of overweight or obese pregnant women with gestational diabetes mellitus. 2. Excessive weight gain during pregnancy according to National Health Institute recommendations may increase the risk of developing pregnancy induced hypertension in comparison to a pregnant women with weight gain less than recommended, but greater than zero. 3. Increased prepregnancy BMI has a role in prediction of birth weight greater than 4300 g, pregnancy induced hypertension, cesarean delivery
摘要

目的

孕产妇超重和肥胖是导致围产期并发症的最重要因素。本研究旨在分析患有妊娠期糖尿病的超重/肥胖孕妇的产科结局,这些结局与美国国立卫生研究院关于孕期体重增加的建议相关,并评估孕前体重指数在预测巨大儿、妊娠期高血压和剖宫产方面的作用。

材料与方法

对209例患有妊娠期糖尿病的超重和肥胖孕妇进行回顾性分析,根据美国国立卫生研究院的建议将其分为4个亚组。分析中纳入了以下数据:诊断妊娠期糖尿病时的孕周;分娩前第一和第三孕期的糖化血红蛋白水平;妊娠期高血压的发生率;剖宫产的发生率;巨大儿的发生率。将第二、三、四亚组的以下数据与被归类为对照组的第一亚组的数据进行比较。还对第二、三、四亚组之间的选定产科参数进行了比较。结果:第二、三、四亚组的选定参数与第一亚组的参数无显著差异。与第三亚组相比,第二亚组中妊娠期高血压的诊断更为频繁。使用ROC曲线分析,发现孕前体重指数在以下预后方面有作用:出生体重超过4300克、妊娠期高血压、剖宫产。

结论

  1. 对于患有妊娠期糖尿病的超重或肥胖孕妇,美国国立卫生研究院关于孕期体重增加的建议的应用有限。2. 与体重增加低于建议但大于零的孕妇相比,根据美国国立卫生研究院建议在孕期过度增重可能会增加患妊娠期高血压的风险。3. 孕前体重指数升高在预测出生体重超过4300克、妊娠期高血压、剖宫产方面有作用

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