Institute of Organic Chemistry of NAS of Ukraine, 5 Murmanska str., Kyiv, 02094, Ukraine.
J Org Chem. 2012 Apr 6;77(7):3365-72. doi: 10.1021/jo300176f. Epub 2012 Mar 12.
A new synthetic approach to 4-substituted imidazo[4,5-c]pyrazoles is proposed on the basis of the N'-(4-halopyrazol-5-yl)amidine cyclization under the conditions of copper-catalyzed cross-coupling reactions. Using 5-aminopyrazoles and copper catalysts as starting materials, the method is inexpensive and convenient and allows a wide range of substituents at all positions of the imidazo[4,5-c]pyrazole nucleus.
提出了一种基于 N'-(4-卤代吡唑-5-基)脒环化的铜催化交叉偶联反应条件下合成 4-取代咪唑并[4,5-c]吡唑的新方法。该方法以 5-氨基吡唑和铜催化剂为起始原料，成本低廉，操作方便，可在咪唑并[4,5-c]吡唑核的所有位置引入各种取代基。
