睾丸癌的环境毒理学。
Environmental toxicology of testicular cancer.
机构信息
Division of Urology, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
出版信息
Urol Oncol. 2012 Mar-Apr;30(2):212-5. doi: 10.1016/j.urolonc.2011.09.009.
OBJECTIVE
Testicular cancer incidence appears to be increasing. In many regions, industrialization results in the production of potentially carcinogenic environmental toxins. We review the available data linking environmental toxins to testicular germ cell tumors (TGCT).
METHODS
A PubMed review of the English literature was performed to identify studies evaluating the relationship between environmental toxins and TGCT.
RESULTS
Many environmental toxins have been implicated in the development of TGCT, including organochlorines, polychlorinated biphenyls, polyvinyl chlorides, phthalates, marijuana, and tobacco. Variable levels of evidence exist and significant study design limitations preclude a definitive etiologic role for individual environmental toxins.
CONCLUSION
Environmental toxins may play an important but undetermined role in the development of TGCT. Further work is needed to evaluate specific toxins and TGCT carcinogenesis.
目的
睾丸癌的发病率似乎正在上升。在许多地区，工业化导致潜在致癌的环境毒素的产生。我们回顾了将环境毒素与睾丸生殖细胞肿瘤（TGCT）联系起来的现有数据。
方法
对 PubMed 英文文献进行了综述，以确定评估环境毒素与 TGCT 之间关系的研究。
结果
许多环境毒素都与 TGCT 的发生有关，包括有机氯、多氯联苯、聚氯乙烯、邻苯二甲酸盐、大麻和烟草。现有证据的水平不一，且研究设计存在重大局限性，无法确定个别环境毒素的病因作用。
结论
环境毒素可能在 TGCT 的发生中起重要但尚未确定的作用。需要进一步的工作来评估特定的毒素和 TGCT 致癌作用。
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