Tishchenko L M
Vrach Delo. 1990 Jul(7):82-6.
The author studied dependence of choice of therapeutic tactics on the immunoglobulin specificity of antithrombocytic autoantibodies in patients with idiopathic autoimmune thrombocytopenic purpura. It was found that in case of detection of antithrombocytic autoantibodies with a IgG specificity the patients are more sensitive to the treatment with glucocorticoids. In case of detection of IgM antithrombocytic autoantibodies, splenectomy at early stages of the disease is more effective.
作者研究了特发性自身免疫性血小板减少性紫癜患者治疗策略的选择与抗血小板自身抗体免疫球蛋白特异性之间的相关性。结果发现,检测到具有IgG特异性的抗血小板自身抗体时,患者对糖皮质激素治疗更为敏感。检测到IgM抗血小板自身抗体时,在疾病早期进行脾切除术更为有效。