Todorova S, Andreeva M, Kirilov G, Matrozov P, Stoianov O, Tsachev K
Vutr Boles. 1990;29(2):74-81.
Calcium-phosphor metabolism was studied in patients with active acromegaly with or without osteoporosis, mean age 45.2 +/- 11.4 years and mean duration of the basic disease 5.52 +/- 3.6 years. No significant deviations and no direct relation with the high serum growth hormone and prolactin levels were found. The normal basic secretion of the calcitrophic hormones--parathyroid hormone and calcitonin and their normal response to the hypercalcemia after intravenous calcium load of the patients with and without osteoporosis reject their direct participation in the pathogenesis of osteopenia. The changed skeletal sensitivity to calcitrophic hormones closely connected with the patients' age and the duration of the basic disease in combination with many other factors probably plays a major role in the pathogenesis of osteopenia.
对患有或未患骨质疏松症的活动性肢端肥大症患者的钙磷代谢进行了研究，患者平均年龄为45.2±11.4岁，基础疾病平均病程为5.52±3.6年。未发现明显偏差，且与高血清生长激素和催乳素水平无直接关系。无论有无骨质疏松症，患者甲状旁腺激素和降钙素等促钙激素的基础分泌正常，且对静脉补钙后高钙血症的正常反应排除了它们直接参与骨质减少发病机制的可能性。骨骼对促钙激素敏感性的改变与患者年龄、基础疾病病程以及许多其他因素密切相关，这可能在骨质减少的发病机制中起主要作用。
