从内部塑造海马体：应激、棘突和 CRH。
Sculpting the hippocampus from within: stress, spines, and CRH.
机构信息
Department of Anatomy/Neurobiology, University of California Irvine, Irvine, CA 92697, USA.
出版信息
Trends Neurosci. 2012 May;35(5):315-24. doi: 10.1016/j.tins.2012.01.005. Epub 2012 Mar 2.
Abstract
Learning and memory processes carried out within the hippocampus are influenced by stress in a complex manner, and the mechanisms by which stress modulates the physiology of the hippocampus are not fully understood. This review addresses how the production and release of the neuropeptide corticotropin-releasing hormone (CRH) within the hippocampus during stress influences neuronal structure and hippocampal function. CRH functions in the contexts of acute and chronic stresses taking place during development, adulthood and aging. Current challenges are to uncover how the dynamic actions of CRH integrate with the well-established roles of adrenal-derived steroid stress hormones to shape the cognitive functions of the hippocampus in response to stress.
摘要
学习和记忆过程在海马体内进行，其受到应激的复杂影响，而应激调节海马体生理学的机制尚不完全清楚。这篇综述探讨了在应激过程中，海马体内神经肽促肾上腺皮质释放激素 (CRH) 的产生和释放如何影响神经元结构和海马体功能。CRH 在发育、成年和衰老期间发生的急性和慢性应激情况下发挥作用。当前的挑战是揭示 CRH 的动态作用如何与肾上腺源性类固醇应激激素的既定作用相整合，以响应应激塑造海马体的认知功能。
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