Institut für Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, Universität Freiburg, 79104 Freiburg, Germany.
Trends Cell Biol. 2012 Apr;22(4):185-92. doi: 10.1016/j.tcb.2012.01.004. Epub 2012 Mar 2.
Mitochondria possess a complex architecture with two membranes. The inner membrane is divided into two domains: the inner boundary membrane, which is adjacent to the outer membrane, and membrane invaginations termed cristae. Both domains are connected by tubular openings, the crista junctions. Recent studies led to the identification of a large protein complex that is crucial for establishing inner-membrane architecture. This mitochondrial inner-membrane organizing system (MINOS) interacts with protein translocases of the outer membrane that are functionally connected to the endoplasmic reticulum (ER)-mitochondria encounter structure. Here, we propose that MINOS forms a central part of an ER-mitochondria organizing network (ERMIONE) that controls mitochondrial membrane architecture and biogenesis.
线粒体具有复杂的双层膜结构。内膜进一步划分为两个区域：与外膜相邻的内界膜和称为嵴的膜内陷。这两个区域通过管状开口——嵴连接部连接。最近的研究鉴定出一个对于构建内膜结构至关重要的大型蛋白复合物，这个复合物被称为线粒体内膜组织系统（MINOS）。MINOS 与功能上与内质网（ER）-线粒体接触结构相连的外膜蛋白移位酶相互作用。在这里，我们提出 MINOS 是 ER-线粒体组织网络（ERMIONE）的核心部分，它控制着线粒体的膜结构和生物发生。
