Department of Clinical Electrophysiology, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People's Republic of China.
Heart Lung. 2012 Jul-Aug;41(4):360-7. doi: 10.1016/j.hrtlng.2012.01.005. Epub 2012 Mar 3.
Previous studies reported an association between the human leukocyte antigen (HLA)-DQ antigen beta 1 chain (DQB1) alleles and dilated cardiomyopathy (DCM). However, the results of those studies have been inconsistent. To clarify the association between HLA-DQB1 and DCM, we performed a systematic review and meta-analysis of case-control studies.
Searches were performed using the PubMed database, the Excerpta Medica Database (EMBASE), the Cochrane Central Register of Controlled Trials database, the Science Citation Index database, the China Biology Medicine disc, the China National Knowledge Information database, the Wanfang database, and the Chinese Scientific and Technological Journal Database (VIP database). The search terms included "dilated cardiomyopathy" and "DQB1." Ten case-controlled studies were included in the systematic review to assess the association between DCM and the HLA-DQB1*0201, *0302, *0504, *0301, and *0602 alleles.
In total, 8 studies were included in the meta-analysis of the HLA-DQB1 *0201 allele. The pooled odds risk (OR) for this allele was .47, with a 95% confidence interval (CI) of .28 to .77 (P < .01). With respect to the HLA-DQB1 *0504 allele, only 3 studies were included in our meta-analysis. The pooled OR was .36 (95% CI, .15 to .84; P < .05). Nine, 8, and 7 studies of the HLA-DQB1 *0301, *0302, and *0602 alleles, respectively, were included in our meta-analysis. No statistically significant difference was evident in the frequency of these 3 alleles between the DCM and normal control groups.
The HLA-DQB1 *0201 and *0504 alleles may be protective against DCM.
先前的研究报告称人类白细胞抗原（HLA）-DQ 抗原β1 链（DQB1）等位基因与扩张型心肌病（DCM）之间存在关联。然而，这些研究的结果并不一致。为了阐明 HLA-DQB1 与 DCM 之间的关联，我们对病例对照研究进行了系统评价和荟萃分析。
使用 PubMed 数据库、Excerpta Medica Database（EMBASE）、Cochrane Central Register of Controlled Trials 数据库、Science Citation Index 数据库、中国生物医学文献数据库、中国国家知识基础设施数据库、万方数据库和中国科技期刊数据库（VIP 数据库）进行检索。检索词包括“扩张型心肌病”和“DQB1”。共纳入 10 项病例对照研究，评估 DCM 与 HLA-DQB1*0201、*0302、*0504、0301 和0602 等位基因之间的关联。
共纳入 8 项 HLA-DQB10201 等位基因荟萃分析研究。该等位基因的合并优势比（OR）为 0.47，95%置信区间（CI）为 0.28 至 0.77（P<0.01）。关于 HLA-DQB10504 等位基因，仅纳入 3 项研究进行荟萃分析。合并 OR 为 0.36（95%CI，0.15 至 0.84；P<0.05）。纳入 HLA-DQB1*0301、0302 和0602 等位基因的研究分别为 9、8 和 7 项。DCM 组和正常对照组之间这些等位基因的频率无统计学差异。
HLA-DQB10201 和0504 等位基因可能对 DCM 具有保护作用。
