为迁移提供正确的拉力：细胞黏附分子在组织运动中的作用。
Giving the right tug for migration: cadherins in tissue movements.
机构信息
KIT Campus South, Zoological Institute, Department of Cell and Developmental Biology, Germany.
出版信息
Arch Biochem Biophys. 2012 Aug 1;524(1):30-42. doi: 10.1016/j.abb.2012.02.013. Epub 2012 Mar 3.
PMID:22387375
Abstract
Dynamically regulated cell-cell adhesion is crucial for morphogenesis during embryonic development and tumor progression. The cadherins as calcium-dependent cell-cell adhesion proteins represent key molecules in these tissue movements. How cadherins serve in maintaining tissue cohesion during migration, facilitate cell-cell communication and promote signaling will be summarized in this review.
摘要
动态调控的细胞间黏附对于胚胎发育和肿瘤进展过程中的形态发生至关重要。钙依赖性细胞间黏附蛋白钙黏蛋白是这些组织运动中的关键分子。本文将综述钙黏蛋白在迁移过程中维持组织内聚力、促进细胞间通讯和促进信号转导中的作用。
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