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无症状性心肌缺血

[Asymptomatic myocardial ischemia].

作者信息

Loskot F, Novotny P

机构信息

Herz- und Kreislaufzentrum, Rotenburg.

出版信息

Z Gesamte Inn Med. 1990 Jul 1;45(13):370-3.

PMID:2238747
Abstract

Silent (asymptomatic) myocardial ischemia (SMI) is defined as a transient alteration in myocardial perfusion in the absence of chest pain or the usual anginal equivalents. Patients may be classified as having one of the three types of SMI: type A--totally asymptomatic patients with no history of angina or myocardial infarction; type B--asymptomatic patients with previous myocardial infarction; type C--patients with angina and asymptomatic ischemic episodes. SMI has been found in 2.5% of all healthy males aged 40-59 and in 20% of all postinfarction patients. In type C-patients, 80% has been found to have asymptomatic ischemic episodes in addition to typical angina pectoris. The frequency of SMI may be up to three or four times that of anginal attacks. SMI patients have generally reduced sensitivity to pain an differences in severity an duration of ischemic episodes. Diagnosis is based on screening by means of exercise testing in patients working in specific professions (like pilots, busdrivers etc.), in postinfarction patients and in patients after unstable angina pectoris and after coronary bypass surgery or coronary angioplasty. Prognosis is the same as in asymptomatic ischemia. SMI is an indicator of instability in certain groups of patients (post infarction, after unstable angina pectoris). SMI persisting after medical therapy of unstable angina is associated with adverse short-term-prognosis, therefore coronary surgery or angioplasty is indicated.

摘要

无症状性心肌缺血(SMI)被定义为在无胸痛或通常的心绞痛等效症状情况下心肌灌注的短暂改变。患者可被归类为患有以下三种类型的SMI之一:A型——完全无症状且无心绞痛或心肌梗死病史的患者;B型——有既往心肌梗死病史的无症状患者;C型——有心绞痛且有无症状性缺血发作的患者。在所有40 - 59岁的健康男性中,2.5%被发现患有SMI,在所有心肌梗死后患者中这一比例为20%。在C型患者中,80%被发现除典型心绞痛外还有无症状性缺血发作。SMI的发作频率可能是心绞痛发作频率的三到四倍。SMI患者通常对疼痛的敏感性降低,缺血发作的严重程度和持续时间也存在差异。诊断基于对从事特定职业的患者(如飞行员、公交车司机等)、心肌梗死后患者、不稳定型心绞痛后患者以及冠状动脉搭桥手术或冠状动脉成形术后患者进行运动试验筛查。预后与无症状性缺血相同。SMI是某些患者群体(心肌梗死后、不稳定型心绞痛后)病情不稳定的一个指标。不稳定型心绞痛药物治疗后仍持续存在的SMI与不良短期预后相关,因此建议进行冠状动脉手术或血管成形术。

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