Mollenkopf C, Steininger H, Weineck G, Meyer M
Pathologisches Institut, Universität Erlangen-Nürnberg.
Z Gastroenterol. 1990 Jul;28(7):327-34.
Granulocyte infiltration was studied in 88 biopsies of antrum mucosa from patients with B-gastritis. Evidence of IgA-, IgG- and IgM-antibodies as well as of lysozyme in the mucosa was demonstrated by immunohistochemical methods. Helicobacter pylori (Hp) is coated by antibodies and a significant correlation between extent of opsonisation and number of plasma cells in the connective tissue of the lamina propria could be stated. Thus, the infiltration of plasma cells is a specific immune response against Hp. In the depths of gastric pits the antibody-coating of bacteria is faint. Instead, lysozyme and lactoferrin are produced there. By means of a Cross-sectional study a model is developed which characterizes B-gastritis as a dynamic process. Lagging behind, the inflammation follows the motile bacteria resulting in a patchy distribution of inflamed areas in the mucosa. At the peak of these local inflammation-waves the production of antibodies and lysozyme is intensified. Coating the bacteria with IgG and IgM results in complement activation liberating chemotaxin C5a. Consequently, there is a massive granulocyte infiltration leading to local reduction or eradication of Hp.
对88例B型胃炎患者的胃窦黏膜活检标本进行了粒细胞浸润研究。采用免疫组化方法证实了黏膜中存在IgA、IgG和IgM抗体以及溶菌酶。幽门螺杆菌（Hp）被抗体包被，且调理作用程度与固有层结缔组织中浆细胞数量之间存在显著相关性。因此，浆细胞浸润是针对Hp的特异性免疫反应。在胃小凹深处，细菌的抗体包被较弱。相反，那里会产生溶菌酶和乳铁蛋白。通过横断面研究建立了一个模型，该模型将B型胃炎描述为一个动态过程。炎症滞后于活动的细菌，导致黏膜中炎症区域呈斑片状分布。在这些局部炎症波的高峰期，抗体和溶菌酶的产生会增强。用IgG和IgM包被细菌会导致补体激活，释放趋化因子C5a。因此，会出现大量粒细胞浸润，导致Hp局部减少或清除。
