一种新的生物活性肼桥联环状二膦化合物的合成、光谱和固态表征。

Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia.

Molecules. 2012 Mar 2;17(3):2567-78. doi: 10.3390/molecules17032567.

The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA.

报告了一种外消旋桥联二膦化合物的简便制备方法，该化合物具有类似于双环[3.3.2]癸烷的环系统。尽管反应产率较低，但该化合物具有八元环、两个膦阳离子中心、双亚氨基桥、分子手性和两个融合的芳环锁定在大致垂直的平面内，其结构不寻常。该化合物在盐水虾试验中表现出显著的生物活性，并能切割质粒 DNA。