Chun-Ye Qian, Xun Shi, Ming Gu
Department of Imaging, Yancheng Health of Vocational and Technical College, Yancheng, Jiangsu Province, China.
Hepatogastroenterology. 2012 Sep;59(118):2000-2. doi: 10.5754/hge12031.
BACKGROUND/AIMS: The aim of the present study was to evaluate the efficacy of TNM staging of pancreatic cancer by multilayer spiral computed tomography (MSCT) and its correlation with tissue PTEN and COX-2 expression.
Fifty-two patients with pancreatic cancer had MSCT for TNM staging and PTEN and COX-2 expression were detected in pancreatic cancer tissue by immunohistochemistry.
The total accuracy of MSCT was 79.5% in diagnosis of TMN staging of pancreatic cancer, with 73.1% for T staging (70.0% in T1, 65.0% in T2, 82.4% in T3 and 80.0% in T4), 76.9% for N staging (81.8% in N0 and 73.3% in N1) and 88.5% for M staging (89.7% in M0 and 84.6% in M1). The PTEN expression was not related to tumor size (p>0.05) but correlated with T staging, lymph node metastasis and clinical staging (p<0.05). COX-2 expression was not related to tumor size and T staging (p>0.05) but correlated with lymph node metastasis and clinical staging (p<0.05).
TNM staging of pancreatic cancer was accurately conducted by MSCT-thin-layer-imaging. The correlation with PTEN and COX-2 expression implied that combined application of both approaches can improve the accuracy of diagnosis and staging in pancreatic cancer.
背景/目的：本研究旨在评估多层螺旋计算机断层扫描（MSCT）对胰腺癌TNM分期的效能及其与组织中PTEN和COX-2表达的相关性。
52例胰腺癌患者接受MSCT进行TNM分期，并通过免疫组织化学检测胰腺癌组织中的PTEN和COX-2表达。
MSCT诊断胰腺癌TMN分期的总准确率为79.5%，T分期为73.1%（T1期为70.0%，T2期为65.0%，T3期为82.4%，T4期为80.0%），N分期为76.9%（N0期为81.8%，N1期为73.3%），M分期为88.5%（M0期为89.7%，M1期为84.6%）。PTEN表达与肿瘤大小无关（p>0.05），但与T分期、淋巴结转移及临床分期相关（p<0.05）。COX-2表达与肿瘤大小和T分期无关（p>0.05），但与淋巴结转移及临床分期相关（p<0.05）。
MSCT薄层成像可准确进行胰腺癌的TNM分期。与PTEN和COX-2表达的相关性表明，两种方法联合应用可提高胰腺癌诊断和分期的准确性。
