The potential importance of Toll-like receptors in ankylosing spondylitis.
作者信息
Tan Filemon K, Farheen Kiran
机构信息
Division of Rheumatology, Department of Internal Medicine, 6431 Fannin, MSB 5.270, Houston, TX 77030, USA.
出版信息
Int J Clin Rheumtol. 2011;6(6):649-654. doi: 10.2217/IJR.11.61.
Abstract
Cells involved in innate immunity scan for pathogens via extracellular and intracellular (endosomal) pattern recognition receptors (PRRs). Engagement of PRRs by a specific ligand results in downstream activation of intracellular inflammatory cascades. There is emerging evidence indicating that one class of PRR, the Toll-like receptor (TLR) plays a potential role in the pathogenesis of spondyloarthropathies. Since certain Gram-negative bacteria are known to act as triggers for reactive arthritis, there has been much interest in studying the role of TLRs in spondyloarthropathies. In this article, we introduce the immunology of TLRs followed by a discussion of their potential role in ankylosing spondylitis.
摘要
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