Toll样受体在强直性脊柱炎中的潜在重要性。
The potential importance of Toll-like receptors in ankylosing spondylitis.
作者信息
Tan Filemon K, Farheen Kiran
机构信息
Division of Rheumatology, Department of Internal Medicine, 6431 Fannin, MSB 5.270, Houston, TX 77030, USA.
出版信息
Int J Clin Rheumtol. 2011;6(6):649-654. doi: 10.2217/IJR.11.61.
Abstract
Cells involved in innate immunity scan for pathogens via extracellular and intracellular (endosomal) pattern recognition receptors (PRRs). Engagement of PRRs by a specific ligand results in downstream activation of intracellular inflammatory cascades. There is emerging evidence indicating that one class of PRR, the Toll-like receptor (TLR) plays a potential role in the pathogenesis of spondyloarthropathies. Since certain Gram-negative bacteria are known to act as triggers for reactive arthritis, there has been much interest in studying the role of TLRs in spondyloarthropathies. In this article, we introduce the immunology of TLRs followed by a discussion of their potential role in ankylosing spondylitis.
摘要
参与固有免疫的细胞通过细胞外和细胞内（内体）模式识别受体（PRR）来扫描病原体。PRR与特定配体的结合会导致细胞内炎症级联反应的下游激活。越来越多的证据表明，一类PRR，即Toll样受体（TLR）在脊柱关节病的发病机制中发挥潜在作用。由于已知某些革兰氏阴性菌是反应性关节炎的触发因素，因此对研究TLR在脊柱关节病中的作用产生了浓厚兴趣。在本文中，我们先介绍TLR的免疫学，然后讨论它们在强直性脊柱炎中的潜在作用。
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