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[对麻疹疫苗接种、再接种及康复者免疫维持持续时间的多年观察结果]

[The results of multiyear observations on the duration of the maintenance of immunity in those vaccinated and revaccinated against and recovered from measles].

作者信息

Sliusar' L I, Sokhin A A, Radomskaia F S, Degtiareva G V, Panasenko L I, Litvinova T P, Komarevskaia R V, Bol'shinskaia Zh I

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1990 Aug(8):66-70.

PMID:2239007
Abstract

The results of 5-year observations on the duration of immunity to measles virus in persons vaccinated and revaccinated against measles, as well as in persons having had this infection, are presented. The intensity of immunity was determined in the same persons with the use of the passive hemagglutination test. The study revealed differences in the formation, intensity and duration of postvaccinal immunity. A significant decrease in the concentration of antibodies over the period of 5 years was established in 50.0-52.3% of vaccines. Revaccination with live measles vaccine is an effective measure for enhancing immunity to measles virus in persons with initial antibody titers less than 1:10-1:20, but revaccination made in a single injection is not sufficient for the stable maintenance of measles morbidity at the sporadic level. Postinfectious immunity is characterized by stability and has no tendency towards decrease. Persons having had measles have no need in additional measures irrespective of the time elapsed after the disease.

摘要

本文介绍了对麻疹疫苗接种者、复种者以及患过麻疹者的麻疹病毒免疫持续时间进行5年观察的结果。使用被动血凝试验测定了同一批人群的免疫强度。研究揭示了疫苗接种后免疫的形成、强度和持续时间存在差异。在50.0% - 52.3%的接种者中,抗体浓度在5年内显著下降。对初始抗体滴度低于1:10 - 1:20的人群,接种麻疹活疫苗是增强对麻疹病毒免疫力的有效措施,但单次注射复种不足以将麻疹发病率稳定维持在散发水平。感染后免疫具有稳定性,没有下降趋势。患过麻疹的人无论患病后经过多长时间都无需采取额外措施。

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