椎管内植入 125I 种子引起的巴纳小型猪的病理性损伤。
Pathological impairments induced by interstitial implantation of 125I seeds in spinal canal of banna mini-pigs.
机构信息
Department of Orthopaedics, Kunming General Hospital of Chengdu Military Command, Kunming, Yunnan 650118, PR China.
出版信息
World J Surg Oncol. 2012 Mar 5;10:48. doi: 10.1186/1477-7819-10-48.
BACKGROUND
Use a banna mini-pig to set up 125I implantation model, and investigate the consequence of radiation-related impairments.
METHODS
In present study, 125I seeds were implanted into spinal canal of T13 level of spine in banna mini-pigs. After operation, the pigs were raised up to 8 months, behavior changes were recorded within this period. After 8 months, spinal cords were collected for pathological analysis.
RESULTS
In this study, a 125I brachytherapy animal model had been successfully established, in the model group, the banna pigs' Tarlov scale decreased from 5 to 2.57 ± 0.36, significant cellular impairments were noted by pathological analysis.
CONCLUSIONS
Without any protection and operation improvement, 125I implantation can cause serious histological impairments and moving difficulty for banna mini-pigs; this present research provides an alternative tool to study spinal 125I brachytherapy.
背景
使用版纳迷你猪建立 125I 植入模型，并研究辐射相关损伤的后果。
方法
本研究将 125I 种子植入版纳迷你猪脊柱 T13 水平椎管内。手术后，猪被饲养了 8 个月，在此期间记录行为变化。8 个月后，收集脊髓进行病理分析。
结果
本研究成功建立了 125I 近距离放疗动物模型，在模型组中，版纳猪的 Tarlov 量表从 5 分降至 2.57 ± 0.36，病理分析显示明显的细胞损伤。
结论
在没有任何保护和手术改进的情况下，125I 植入会导致版纳迷你猪严重的组织学损伤和运动困难；本研究为研究脊柱 125I 近距离放疗提供了一种替代工具。
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