Shapiro I M, Neufeld M Y, Korczyn A D
Department of Neurology, Sackler School of Medicine, Tel Aviv University, Israel.
Acta Neurol Scand. 1990 Jul;82(1):78-80. doi: 10.1111/j.1600-0404.1990.tb01591.x.
To investigate the possible etiologic factors of late onset seizures of unknown origin, 50 consecutive patients whose seizures started after age 50 and who had a normal CT, were screened. The seizures in this group were generalized in 70% and infrequent. The hypothesis that late-onset seizures of unknown origin were frequently due to microinfarcts, was evaluated by comparing the frequency of arterial hypertension, coronary heart disease, peripheral vascular disease, carotid bruits, diabetes mellitus and smoking in these patients with appropriate control groups. The results showed that the frequencies of these cardiovascular risk factors were similar to those of sex and age-matched controls and much lower than in a comparable series of patients whose seizures followed a stroke, or patients with stroke but not seizures. These data suggest that subclinical cerebrovascular disease is probably not a frequent etiology of late-onset epilepsy of unknown origin. The cause of these seizures remains to be elucidated.
为了研究不明原因迟发性癫痫发作的可能病因，我们对50例50岁以后发病且CT检查正常的连续患者进行了筛查。该组患者中70%的癫痫发作为全身性发作且发作不频繁。通过比较这些患者与适当对照组中动脉高血压、冠心病、外周血管疾病、颈动脉杂音、糖尿病和吸烟的发生率，评估了不明原因迟发性癫痫发作常因微梗死所致的假说。结果显示，这些心血管危险因素的发生率与性别和年龄匹配的对照组相似，且远低于癫痫发作继发于中风的类似患者系列或有中风但无癫痫发作的患者。这些数据表明，亚临床脑血管疾病可能不是不明原因迟发性癫痫的常见病因。这些癫痫发作的原因仍有待阐明。
